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DNA repair deficiency in neuropathogenesis: when all roads lead to mitochondria
Mutations in DNA repair enzymes can cause two neurological clinical manifestations: a developmental impairment and a degenerative disease. Polynucleotide kinase 3′-phosphatase (PNKP) is an enzyme that is actively involved in DNA repair in both single and double strand break repair systems. Mutations...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511134/ https://www.ncbi.nlm.nih.gov/pubmed/31110700 http://dx.doi.org/10.1186/s40035-019-0156-x |