Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28

LIN28 is an RNA-binding protein that regulates the maturation of the let-7 family of microRNAs by bipartite interactions with let-7 precursors through its two distinct cold shock and zinc-knuckle domains. Through inhibition of let-7 biogenesis, LIN28 functions as a pluripotency factor, as well as a...

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Detalles Bibliográficos
Autores principales: Wang, Longfei, Rowe, R. Grant, Jaimes, Adriana, Yu, Chunxiao, Nam, Yunsun, Pearson, Daniel S., Zhang, Jin, Xie, Xiangyu, Marion, William, Heffron, Gregory J., Daley, George Q., Sliz, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511231/
https://www.ncbi.nlm.nih.gov/pubmed/29874593
http://dx.doi.org/10.1016/j.celrep.2018.04.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511231/
https://www.ncbi.nlm.nih.gov/pubmed/29874593
http://dx.doi.org/10.1016/j.celrep.2018.04.116

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