A complex between DYRK1A and DCAF7 phosphorylates the C-terminal domain of RNA polymerase II to promote myogenesis

The general transcription factor P-TEFb, a master regulator of RNA polymerase (Pol) II elongation, phosphorylates the C-terminal domain (CTD) of Pol II and negative elongation factors to release Pol II from promoter-proximal pausing. We show here that P-TEFb surprisingly inhibits the myoblast differ...

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Detalles Bibliográficos
Autores principales: Yu, Dan, Cattoglio, Claudia, Xue, Yuhua, Zhou, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511856/
https://www.ncbi.nlm.nih.gov/pubmed/30864669
http://dx.doi.org/10.1093/nar/gkz162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511856/
https://www.ncbi.nlm.nih.gov/pubmed/30864669
http://dx.doi.org/10.1093/nar/gkz162

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