Cargando…
A complex between DYRK1A and DCAF7 phosphorylates the C-terminal domain of RNA polymerase II to promote myogenesis
The general transcription factor P-TEFb, a master regulator of RNA polymerase (Pol) II elongation, phosphorylates the C-terminal domain (CTD) of Pol II and negative elongation factors to release Pol II from promoter-proximal pausing. We show here that P-TEFb surprisingly inhibits the myoblast differ...
Autores principales: | Yu, Dan, Cattoglio, Claudia, Xue, Yuhua, Zhou, Qiang |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511856/ https://www.ncbi.nlm.nih.gov/pubmed/30864669 http://dx.doi.org/10.1093/nar/gkz162 |
Ejemplares similares
-
CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation
por: Tellier, Michael, et al.
Publicado: (2020) -
Phosphorylation of the carboxy-terminal domain of histone H1: effects on secondary structure and DNA condensation
por: Roque, Alicia, et al.
Publicado: (2008) -
Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast
por: Inada, Maki, et al.
Publicado: (2016) -
Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation
por: Itzen, Friederike, et al.
Publicado: (2014) -
Bacteriophage Xp10 anti-termination factor p7 induces forward translocation by host RNA polymerase
por: Zenkin, Nikolay, et al.
Publicado: (2015)