Flexizyme-catalyzed synthesis of 3′-aminoacyl-NH-tRNAs

Structural analysis of ribosomes in complex with aminoacyl- and/or peptidyl-transfer RNA (tRNA) often suffers from rapid hydrolysis of the ester bond of aminoacyl-tRNAs. To avoid this issue, several methods to introduce an unhydrolyzable amide bond instead of the canonical ester bond have been devel...

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Detalles Bibliográficos
Autores principales: Katoh, Takayuki, Suga, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511858/
https://www.ncbi.nlm.nih.gov/pubmed/30843032
http://dx.doi.org/10.1093/nar/gkz143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511858/
https://www.ncbi.nlm.nih.gov/pubmed/30843032
http://dx.doi.org/10.1093/nar/gkz143

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