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Flexizyme-catalyzed synthesis of 3′-aminoacyl-NH-tRNAs
Structural analysis of ribosomes in complex with aminoacyl- and/or peptidyl-transfer RNA (tRNA) often suffers from rapid hydrolysis of the ester bond of aminoacyl-tRNAs. To avoid this issue, several methods to introduce an unhydrolyzable amide bond instead of the canonical ester bond have been devel...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511858/ https://www.ncbi.nlm.nih.gov/pubmed/30843032 http://dx.doi.org/10.1093/nar/gkz143 |