Determining selection free energetics from nucleotide pre-insertion to insertion in viral T7 RNA polymerase transcription fidelity control

An elongation cycle of a transcribing RNA polymerase (RNAP) usually consists of multiple kinetics steps, so there exist multiple kinetic checkpoints where non-cognate nucleotides can be selected against. We conducted comprehensive free energy calculations on various nucleotide insertions for viral T...

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Detalles Bibliográficos
Autores principales: Long, Chunhong, E, Chao, Da, Lin-Tai, Yu, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511863/
https://www.ncbi.nlm.nih.gov/pubmed/30916310
http://dx.doi.org/10.1093/nar/gkz213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511863/
https://www.ncbi.nlm.nih.gov/pubmed/30916310
http://dx.doi.org/10.1093/nar/gkz213

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