GSK3β-SCF(FBXW7α) mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover

IRF1 (Interferon Regulatory Factor-1) is the prototype of the IRF family of DNA binding transcription factors. IRF1 protein expression is regulated by transient up-regulation in response to external stimuli followed by rapid degradation via the ubiquitin-proteasome system. Here we report that DNA bo...

Descripción completa

Detalles Bibliográficos
Autores principales: Garvin, Alexander J, Khalaf, Ahmed H A, Rettino, Alessandro, Xicluna, Jerome, Butler, Laura, Morris, Joanna R, Heery, David M, Clarke, Nicole M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511875/
https://www.ncbi.nlm.nih.gov/pubmed/30854564
http://dx.doi.org/10.1093/nar/gkz163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511875/
https://www.ncbi.nlm.nih.gov/pubmed/30854564
http://dx.doi.org/10.1093/nar/gkz163

Ejemplares similares