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GSK3β-SCF(FBXW7α) mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover

IRF1 (Interferon Regulatory Factor-1) is the prototype of the IRF family of DNA binding transcription factors. IRF1 protein expression is regulated by transient up-regulation in response to external stimuli followed by rapid degradation via the ubiquitin-proteasome system. Here we report that DNA bo...

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Detalles Bibliográficos
Autores principales:	Garvin, Alexander J, Khalaf, Ahmed H A, Rettino, Alessandro, Xicluna, Jerome, Butler, Laura, Morris, Joanna R, Heery, David M, Clarke, Nicole M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511875/ https://www.ncbi.nlm.nih.gov/pubmed/30854564 http://dx.doi.org/10.1093/nar/gkz163

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