RNase H activities counteract a toxic effect of Polymerase η in cells replicating with depleted dNTP pools

RNA:DNA hybrids are transient physiological intermediates that arise during several cellular processes such as DNA replication. In pathological situations, they may stably accumulate and pose a threat to genome integrity. Cellular RNase H activities process these structures to restore the correct DN...

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Detalles Bibliográficos
Autores principales: Meroni, Alice, Nava, Giulia Maria, Bianco, Eliana, Grasso, Lavinia, Galati, Elena, Bosio, Maria Cristina, Delmastro, Daria, Muzi-Falconi, Marco, Lazzaro, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511917/
https://www.ncbi.nlm.nih.gov/pubmed/30847483
http://dx.doi.org/10.1093/nar/gkz165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511917/
https://www.ncbi.nlm.nih.gov/pubmed/30847483
http://dx.doi.org/10.1093/nar/gkz165

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