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HIF1α-Induced Glycolysis in Macrophage Is Essential for the Protective Effect of Ouabain during Endotoxemia

Ouabain, a steroid binding to the Na(+)/K(+)-ATPase, has several pharmacological effects. In addition to the recognized effects of blood pressure, there is more convincing evidence suggesting that ouabain is involved in immunologic functions and inflammation. Hypoxia-inducible factor 1α (HIF-1α) is...

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Detalles Bibliográficos
Autores principales: Shao, Chao, Lin, Shengwei, Liu, Sudan, Jin, Peipei, Lu, Wenbin, Li, Na, Zhang, Yan, Bo, Lulong, Bian, Jinjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512009/
https://www.ncbi.nlm.nih.gov/pubmed/31182997
http://dx.doi.org/10.1155/2019/7136585