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Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm–Associated Regions to Potential Candidate Genes

BACKGROUND: We previously showed that intracranial aneurysm (IA)–associated single‐nucleotide polymorphisms are enriched in promoters and putative enhancers identified in the human circle of Willis, on which IAs develop, suggesting a role for promoters and enhancers in IAs. We further investigated t...

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Detalles Bibliográficos
Autores principales: Laarman, Melanie D., Geeven, Geert, Barnett, Phil, Rinkel, Gabriël J. E., de Laat, Wouter, Ruigrok, Ynte M., Bakkers, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512097/
https://www.ncbi.nlm.nih.gov/pubmed/30994044
http://dx.doi.org/10.1161/JAHA.118.011201