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Rapid production of a chimeric antibody-antigen fusion protein based on 2A-peptide cleavage and green fluorescent protein expression in CHO cells

To enable large-scale antibody production, the creation of a stable, high producer cell line is essential. This process often takes longer than 6 months using standard limited dilution techniques and is very labor intensive. The use of a tri-cistronic vector expressing green fluorescent protein (GFP...

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Detalles Bibliográficos
Autores principales: Van der Weken, Hans, Cox, Eric, Devriendt, Bert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512901/
https://www.ncbi.nlm.nih.gov/pubmed/30694096
http://dx.doi.org/10.1080/19420862.2019.1574531