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Malignant manipulaTORs of metabolism: suppressing BCAA catabolism to enhance mTORC1 activity
The mammalian target of rapamycin complex 1 (mTORC1) plays an important role in the development and progression of multiple cancers. Its activity is regulated by both growth factor and nutrient signals, and the branched-chain amino acid (BCAA) leucine plays an important and unique role in this proce...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512911/ https://www.ncbi.nlm.nih.gov/pubmed/31131306 http://dx.doi.org/10.1080/23723556.2019.1585171 |