Malignant manipulaTORs of metabolism: suppressing BCAA catabolism to enhance mTORC1 activity

The mammalian target of rapamycin complex 1 (mTORC1) plays an important role in the development and progression of multiple cancers. Its activity is regulated by both growth factor and nutrient signals, and the branched-chain amino acid (BCAA) leucine plays an important and unique role in this proce...

Descripción completa

Detalles Bibliográficos
Autores principales: Ericksen, Russell E., Han, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512911/
https://www.ncbi.nlm.nih.gov/pubmed/31131306
http://dx.doi.org/10.1080/23723556.2019.1585171
_version_ 1783417706819616768
author Ericksen, Russell E.
Han, Weiping
author_facet Ericksen, Russell E.
Han, Weiping
author_sort Ericksen, Russell E.
collection PubMed
description The mammalian target of rapamycin complex 1 (mTORC1) plays an important role in the development and progression of multiple cancers. Its activity is regulated by both growth factor and nutrient signals, and the branched-chain amino acid (BCAA) leucine plays an important and unique role in this process. Recently we found that cancers of the liver and multiple other tissues suppress the catabolism of BCAAs, thereby facilitating the chronic activation of mTORC1. Our results unveil how mTORC1’s nutrient-sensing arm can be manipulated by tumors, and suggest that restoring BCAA catabolism may help control mTORC1 activity in cancer cells.
format Online
Article
Text
id pubmed-6512911
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-65129112020-03-20 Malignant manipulaTORs of metabolism: suppressing BCAA catabolism to enhance mTORC1 activity Ericksen, Russell E. Han, Weiping Mol Cell Oncol Author's Views The mammalian target of rapamycin complex 1 (mTORC1) plays an important role in the development and progression of multiple cancers. Its activity is regulated by both growth factor and nutrient signals, and the branched-chain amino acid (BCAA) leucine plays an important and unique role in this process. Recently we found that cancers of the liver and multiple other tissues suppress the catabolism of BCAAs, thereby facilitating the chronic activation of mTORC1. Our results unveil how mTORC1’s nutrient-sensing arm can be manipulated by tumors, and suggest that restoring BCAA catabolism may help control mTORC1 activity in cancer cells. Taylor & Francis 2019-03-20 /pmc/articles/PMC6512911/ /pubmed/31131306 http://dx.doi.org/10.1080/23723556.2019.1585171 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Ericksen, Russell E.
Han, Weiping
Malignant manipulaTORs of metabolism: suppressing BCAA catabolism to enhance mTORC1 activity
title Malignant manipulaTORs of metabolism: suppressing BCAA catabolism to enhance mTORC1 activity
title_full Malignant manipulaTORs of metabolism: suppressing BCAA catabolism to enhance mTORC1 activity
title_fullStr Malignant manipulaTORs of metabolism: suppressing BCAA catabolism to enhance mTORC1 activity
title_full_unstemmed Malignant manipulaTORs of metabolism: suppressing BCAA catabolism to enhance mTORC1 activity
title_short Malignant manipulaTORs of metabolism: suppressing BCAA catabolism to enhance mTORC1 activity
title_sort malignant manipulators of metabolism: suppressing bcaa catabolism to enhance mtorc1 activity
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512911/
https://www.ncbi.nlm.nih.gov/pubmed/31131306
http://dx.doi.org/10.1080/23723556.2019.1585171
work_keys_str_mv AT ericksenrusselle malignantmanipulatorsofmetabolismsuppressingbcaacatabolismtoenhancemtorc1activity
AT hanweiping malignantmanipulatorsofmetabolismsuppressingbcaacatabolismtoenhancemtorc1activity

Ejemplares similares