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C(H)2 domain orientation of human immunoglobulin G in solution: Structural comparison of glycosylated and aglycosylated Fc regions using small-angle X-ray scattering

The N-linked glycan in immunoglobulin G is critical for the stability and function of the crystallizable fragment (Fc) region. Alteration of these protein properties upon the removal of the N-linked glycan has often been explained by the alteration of the C(H)2 domain orientation in the Fc region. T...

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Detalles Bibliográficos
Autores principales: Yageta, Seiki, Imamura, Hiroshi, Shibuya, Risa, Honda, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512918/
https://www.ncbi.nlm.nih.gov/pubmed/30513259
http://dx.doi.org/10.1080/19420862.2018.1546086