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Dilute-and-shoot analysis of therapeutic monoclonal antibody variants in fermentation broth: a method capability study

Monoclonal antibodies (mAbs) are widely applied as highly specific and efficient therapeutic agents for various medical conditions, including cancer, inflammatory and autoimmune diseases. As protein production in cellular systems inherently generates a multitude of molecular variants, manufacturing...

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Detalles Bibliográficos
Autores principales: Regl, Christof, Wohlschlager, Therese, Esser-Skala, Wolfgang, Wagner, Iris, Samonig, Martin, Holzmann, Johann, Huber, Christian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512939/
https://www.ncbi.nlm.nih.gov/pubmed/30668249
http://dx.doi.org/10.1080/19420862.2018.1563034