A recycling anti-transferrin receptor-1 monoclonal antibody as an efficient therapy for erythroleukemia through target up-regulation and antibody-dependent cytotoxic effector functions

Targeting transferrin receptor 1 (TfR1) with monoclonal antibodies is a promising therapeutic strategy in cancer as tumor cells often overexpress TfR1 and show increased iron needs. We have re-engineered six anti-human TfR1 single-chain variable fragment (scFv) antibodies into fully human scFv(2)-Fc...

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Detalles Bibliográficos
Autores principales: Neiveyans, Madeline, Melhem, Rana, Arnoult, Christophe, Bourquard, Thomas, Jarlier, Marta, Busson, Muriel, Laroche, Adrien, Cerutti, Martine, Pugnière, Martine, Ternant, David, Gaborit, Nadège, Chardès, Thierry, Poupon, Anne, Gouilleux-Gruart, Valérie, Pèlegrin, Andre, Poul, Marie-Alix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512944/
https://www.ncbi.nlm.nih.gov/pubmed/30604643
http://dx.doi.org/10.1080/19420862.2018.1564510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512944/
https://www.ncbi.nlm.nih.gov/pubmed/30604643
http://dx.doi.org/10.1080/19420862.2018.1564510

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