Castration-resistant prostate cancer: Androgen receptor inactivation induces telomere DNA damage, and damage response inhibition leads to cell death

Telomere stability is important for cell viability, as cells with telomere DNA damage that is not repaired do not survive. We reported previously that androgen receptor (AR) antagonist induces telomere DNA damage in androgen-sensitive LNCaP prostate cancer cells; this triggers a DNA damage response...

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Detalles Bibliográficos
Autores principales: Reddy, Vidyavathi, Iskander, Asm, Hwang, Clara, Divine, George, Menon, Mani, Barrack, Evelyn R., Reddy, G. Prem-Veer, Kim, Sahn-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513077/
https://www.ncbi.nlm.nih.gov/pubmed/31083651
http://dx.doi.org/10.1371/journal.pone.0211090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513077/
https://www.ncbi.nlm.nih.gov/pubmed/31083651
http://dx.doi.org/10.1371/journal.pone.0211090

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