Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design

Antibodies are an important class of therapeutics that have significant clinical impact for the treatment of severe diseases. Computational tools to support antibody drug discovery have been developing at an increasing rate over the last decade and typically rely upon a predetermined co-crystal stru...

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Detalles Bibliográficos
Autores principales: Cannon, Daniel A., Shan, Lu, Du, Qun, Shirinian, Lena, Rickert, Keith W., Rosenthal, Kim L., Korade, Martin, van Vlerken-Ysla, Lilian E., Buchanan, Andrew, Vaughan, Tristan J., Damschroder, Melissa M., Popovic, Bojana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513101/
https://www.ncbi.nlm.nih.gov/pubmed/31042706
http://dx.doi.org/10.1371/journal.pcbi.1006980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513101/
https://www.ncbi.nlm.nih.gov/pubmed/31042706
http://dx.doi.org/10.1371/journal.pcbi.1006980

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