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Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design
Antibodies are an important class of therapeutics that have significant clinical impact for the treatment of severe diseases. Computational tools to support antibody drug discovery have been developing at an increasing rate over the last decade and typically rely upon a predetermined co-crystal stru...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513101/ https://www.ncbi.nlm.nih.gov/pubmed/31042706 http://dx.doi.org/10.1371/journal.pcbi.1006980 |