Justicidin A Reduces β-Amyloid via Inhibiting Endocytosis of β-Amyloid Precursor Protein

β-amyloid precursor protein (APP) can be cleaved by α-, and γ-secretase at plasma membrane producing soluble ectodomain fragment (sAPPα). Alternatively, following endocytosis, APP is cleaved by β-, and γ-secretase at early endosomes generating β-amyloid (Aβ), the main culprit in Alzheimer’s disease...

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Detalles Bibliográficos
Autores principales: Chun, Yoon Sun, Kwon, Oh-Hoon, Oh, Hyun Geun, Cho, Yoon Young, Yang, Hyun Ok, Chung, Sungkwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513189/
https://www.ncbi.nlm.nih.gov/pubmed/30332887
http://dx.doi.org/10.4062/biomolther.2018.112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513189/
https://www.ncbi.nlm.nih.gov/pubmed/30332887
http://dx.doi.org/10.4062/biomolther.2018.112

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