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MAVS polymers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling
Double‐stranded RNA (dsRNA) is a potent proinflammatory signature of viral infection and is sensed primarily by RIG‐I‐like receptors (RLRs). Oligomerization of RLRs following binding to cytosolic dsRNA activates and nucleates self‐assembly of the mitochondrial antiviral‐signaling protein (MAVS). In...
Autores principales: | Hwang, Ming‐Shih, Boulanger, Jérôme, Howe, Jonathan D., Albecka, Anna, Pasche, Mathias, Mureşan, Leila, Modis, Yorgo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513760/ https://www.ncbi.nlm.nih.gov/pubmed/30715798 http://dx.doi.org/10.1111/febs.14772 |
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