Impaired SIRT1 activity leads to diminution in glomerular endowment without accelerating age‐associated GFR decline

Glomerular filtration rate (GFR) declines with age such that the prevalence of chronic kidney disease is much higher in the elderly. SIRT1 is the leading member of the sirtuin family of NAD (+)‐dependent lysine deacetylases that mediate the health span extending properties of caloric restriction. Si...

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Detalles Bibliográficos
Autores principales: Bellin, Ashley R., Zhang, Yanling, Thai, Kerri, Rosenblum, Norman D., Cullen‐McEwen, Luise A., Bertram, John F., Gilbert, Richard E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513772/
https://www.ncbi.nlm.nih.gov/pubmed/31087539
http://dx.doi.org/10.14814/phy2.14044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513772/
https://www.ncbi.nlm.nih.gov/pubmed/31087539
http://dx.doi.org/10.14814/phy2.14044

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