The Impact of Pre-existing Immunity on the Non-clinical Pharmacodynamics of AAV5-Based Gene Therapy

Adeno-associated virus (AAV)-based vectors are widely used for gene therapy, but the effect of pre-existing antibodies resulting from exposure to wild-type AAV is unclear. In addition, other poorly defined plasma factors could inhibit AAV vector transduction where antibodies are not detected. To bet...

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Detalles Bibliográficos
Autores principales: Long, Brian R., Sandza, Krystal, Holcomb, Jennifer, Crockett, Lucy, Hayes, Gregory M., Arens, Jeremy, Fonck, Carlos, Tsuruda, Laurie S., Schweighardt, Becky, O’Neill, Charles A., Zoog, Stephen, Vettermann, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513774/
https://www.ncbi.nlm.nih.gov/pubmed/31193016
http://dx.doi.org/10.1016/j.omtm.2019.03.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513774/
https://www.ncbi.nlm.nih.gov/pubmed/31193016
http://dx.doi.org/10.1016/j.omtm.2019.03.006

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