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The activity of the saponin ginsenoside Rh2 is enhanced by the interaction with membrane sphingomyelin but depressed by cholesterol
The membrane activity of some saponins, such as digitonin or alpha-hederin, is usually attributed to their interaction with membrane cholesterol (Chol). This contrasts with our recent publication showing that Chol, contrary to sphingomyelin (SM), can delay the cytotoxicity of the saponin ginsenoside...
Autores principales: | Verstraeten, Sandrine L., Deleu, Magali, Janikowska-Sagan, Maria, Claereboudt, Emily J. S., Lins, Laurence, Tyteca, Donatienne, Mingeot-Leclercq, Marie-Paule |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513819/ https://www.ncbi.nlm.nih.gov/pubmed/31086211 http://dx.doi.org/10.1038/s41598-019-43674-w |
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