Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB

Extracellular lysyl oxidases (LOX and LOXL1–LOXL4) are critical for collagen biosynthesis. LOXL2 is a marker of poor survival in oral squamous cell cancer. We investigated mechanisms by which tumor cell secreted LOXL2 targets proximal mesenchymal cells to enhance tumor growth and metastasis. This st...

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Detalles Bibliográficos
Autores principales: Mahjour, Faranak, Dambal, Vrinda, Shrestha, Neha, Singh, Varun, Noonan, Vikki, Kantarci, Alpdogan, Trackman, Philip C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513832/
https://www.ncbi.nlm.nih.gov/pubmed/31086173
http://dx.doi.org/10.1038/s41389-019-0144-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513832/
https://www.ncbi.nlm.nih.gov/pubmed/31086173
http://dx.doi.org/10.1038/s41389-019-0144-0

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