HPV18 Utilizes Two Alternative Branch Sites for E6*I Splicing to Produce E7 Protein

Human papillomavirus 18 (HPV18) E6 and E7 oncogenes are transcribed as a single bicistronic E6E7 pre-mRNA. The E6 ORF region in the bicistronic E6E7 pre-mRNA contains an intron. Splicing of this intron disrupts the E6 ORF integrity and produces a spliced E6*I RNA for efficient E7 translation. Here w...

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Detalles Bibliográficos
Autores principales: Brant, Ayslan Castro, Majerciak, Vladimir, Moreira, Miguel Angelo Martins, Zheng, Zhi-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513837/
https://www.ncbi.nlm.nih.gov/pubmed/30945125
http://dx.doi.org/10.1007/s12250-019-00098-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513837/
https://www.ncbi.nlm.nih.gov/pubmed/30945125
http://dx.doi.org/10.1007/s12250-019-00098-0

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