EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks

The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is necessary for the repair of DNA double-strand breaks (DSBs) in human cells and that RNA clearance is an essential step in homologous recombination. Transcription of DSB-flanking se...

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Detalles Bibliográficos
Autores principales: Domingo-Prim, Judit, Endara-Coll, Martin, Bonath, Franziska, Jimeno, Sonia, Prados-Carvajal, Rosario, Friedländer, Marc R., Huertas, Pablo, Visa, Neus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513946/
https://www.ncbi.nlm.nih.gov/pubmed/31086179
http://dx.doi.org/10.1038/s41467-019-10153-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513946/
https://www.ncbi.nlm.nih.gov/pubmed/31086179
http://dx.doi.org/10.1038/s41467-019-10153-9

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