Cargando…

Molecular basis for heat desensitization of TRPV1 ion channels

The transient receptor potential vanilloid 1 (TRPV1) ion channel is a prototypical molecular sensor for noxious heat in mammals. Its role in sustained heat response remains poorly understood, because rapid heat-induced desensitization (Dh) follows tightly heat-induced activation (Ah). To understand...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Lei, Wang, Yunfei, Li, Bowen, Xu, Lizhen, Kamau, Peter Muiruri, Zheng, Jie, Yang, Fan, Yang, Shilong, Lai, Ren
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513986/ https://www.ncbi.nlm.nih.gov/pubmed/31086183 http://dx.doi.org/10.1038/s41467-019-09965-6

Ejemplares similares

Author Correction: Molecular basis for heat desensitization of TRPV1 ion channels
por: Luo, Lei, et al.
Publicado: (2020)

The Latoia consocia Caterpillar Induces Pain by Targeting Nociceptive Ion Channel TRPV1
por: Yao, Zhihao, et al.
Publicado: (2019)

Centipede Venom: A Potential Source of Ion Channel Modulators
por: Luo, Anna, et al.
Publicado: (2022)

Vertebrate OTOP1 is also an alkali-activated channel
por: Tian, Lifeng, et al.
Publicado: (2023)

Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel
por: Hakim, Md Abdul, et al.
Publicado: (2015)

A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1
por: Yang, Shilong, et al.
Publicado: (2015)

An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel
por: Yang, Fan, et al.
Publicado: (2020)

Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel
por: Zhen, Wenxuan, et al.
Publicado: (2023)

Molecular game theory for a toxin-dominant food chain model
por: Li, Bowen, et al.
Publicado: (2019)

TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation
por: Huang, Susan M, et al.
Publicado: (2011)

Thermoring Basis for the Heat Inactivation in TRPV1
por: Wang, Guangyu
Publicado: (2023)

Molecular Basis of IgE-Mediated Shrimp Allergy and Heat Desensitization
por: Zhang, PeiAo, et al.
Publicado: (2021)

De Novo Design of Peptidic Positive Allosteric Modulators Targeting TRPV1 with Analgesic Effects
por: Xu, Lizhen, et al.
Publicado: (2021)

Divalent cations potentiate TRPV1 channel by lowering the heat activation threshold
por: Cao, Xu, et al.
Publicado: (2014)

Nicotinic Acid is a Common Regulator of Heat-Sensing TRPV1-4 Ion Channels
por: Ma, Linlin, et al.
Publicado: (2015)

Structural mechanism underlying capsaicin binding and activation of TRPV1 ion channel
por: Yang, Fan, et al.
Publicado: (2015)

Bioactive Peptides and Proteins from Wasp Venoms
por: Luo, Lei, et al.
Publicado: (2022)

The role of TRPA1 channels in thermosensation
por: Zhang, Hao, et al.
Publicado: (2022)

Structural basis of temperature sensation by the TRP channel TRPV3
por: Singh, Appu K., et al.
Publicado: (2019)

Conformational Plasticity in the Selectivity Filter of the TRPV2 Ion Channel
por: Zubcevic, Lejla, et al.
Publicado: (2018)

Endocannabinoid activation of the TRPV1 ion channel is distinct from activation by capsaicin
por: Li, Yanxin, et al.
Publicado: (2021)

The acquisition of cold sensitivity during TRPM8 ion channel evolution
por: Lu, Xiancui, et al.
Publicado: (2022)

Bioactive Peptides and Proteins from Centipede Venoms
por: Han, Yalan, et al.
Publicado: (2022)

The capsaicin binding affinity of wildtype and mutant TRPV1 ion channels
por: Li, Shisheng, et al.
Publicado: (2023)

Molecular mechanism underlying modulation of TRPV1 heat activation by polyols
por: Nie, Yingying, et al.
Publicado: (2021)

Conformational ensemble of the human TRPV3 ion channel
por: Zubcevic, Lejla, et al.
Publicado: (2018)

TRPV3 Ion Channel: From Gene to Pharmacology
por: Kalinovskii, Aleksandr P., et al.
Publicado: (2023)

Supraspinal-selective TRPV1 desensitization induced by intracerebroventricular treatment with resiniferatoxin
por: Fukushima, Akihiro, et al.
Publicado: (2017)

The role of TRPV1 ion channels in the suppression of gastric cancer development
por: Gao, Nannan, et al.
Publicado: (2020)

Understand spiciness: mechanism of TRPV1 channel activation by capsaicin
por: Yang, Fan, et al.
Publicado: (2017)

The heat is on! TRPV1 channels and resistance artery myogenic tone
por: Jackson, William F.
Publicado: (2022)

Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations
por: Cui, Yuanyuan, et al.
Publicado: (2012)

A proinflammatory chemokine, CCL3, sensitizes the heat-gated and capsaicin-gated ion channel, TRPV1
por: Zhang, N, et al.
Publicado: (2004)

Warmth suppresses and desensitizes damage-sensing ion channel TRPA1
por: Wang, Sen, et al.
Publicado: (2012)

A paradigm of thermal adaptation in penguins and elephants by tuning cold activation in TRPM8
por: Yang, Shilong, et al.
Publicado: (2020)

Cryo-electron microscopy structure of the TRPV2 ion channel
por: Zubcevic, Lejla, et al.
Publicado: (2016)

Mechanism for phosphoinositide selectivity and activation of TRPV1 ion channels
por: Ufret-Vincenty, Carmen A., et al.
Publicado: (2015)

TRPV4 is the temperature-sensitive ion channel of human sperm
por: Mundt, Nadine, et al.
Publicado: (2018)

TRPV4: A Physio and Pathophysiologically Significant Ion Channel
por: Rosenbaum, Tamara, et al.
Publicado: (2020)

Desensitization of TRPV1 Involved in the Antipruritic Effect of Osthole on Histamine-Induced Scratching Behavior in Mice
por: Yang, Niuniu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9v9qfpi6apd4h88e89njjoaqos