Impairment of HIF-1α-mediated metabolic adaption by NRF2-silencing in breast cancer cells

Hypoxia, a common element in the tumor environment, leads to Hypoxia-Inducible Factor-1α (HIF-1α) stabilization to modulate cellular metabolism as an adaptive response. In a previous study, we showed that inhibition of the nuclear factor erythroid 2-like-2 (NFE2L2; NRF2), a master regulator of many...

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Detalles Bibliográficos
Autores principales: Lee, Sujin, Hallis, Steffanus Pranoto, Jung, Kyeong-Ah, Ryu, Dayoung, Kwak, Mi-Kyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514540/
https://www.ncbi.nlm.nih.gov/pubmed/31078780
http://dx.doi.org/10.1016/j.redox.2019.101210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514540/
https://www.ncbi.nlm.nih.gov/pubmed/31078780
http://dx.doi.org/10.1016/j.redox.2019.101210

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