Synthesis of Chromen-4-One-Oxadiazole Substituted Analogs as Potent β-Glucuronidase Inhibitors

Chromen-4-one substituted oxadiazole analogs 1–19 have been synthesized, characterized and evaluated for β-glucuronidase inhibition. All analogs exhibited a variable degree of β-glucuronidase inhibitory activity with IC(50) values ranging in between 0.8 ± 0.1–42.3 ± 0.8 μM when compared with the sta...

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Detalles Bibliográficos
Autores principales: Taha, Muhammad, Rahim, Fazal, Ali, Muhammad, Khan, Muhammad Naseem, Alqahtani, Mohammed A., Bamarouf, Yasser A., Gollapalli, Mohammed, Farooq, Rai Khalid, Shah, Syed Adnan Ali, Ahmed, Qamar Uddin, Zakaria, Zainul Amiruddin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514607/
https://www.ncbi.nlm.nih.gov/pubmed/31003424
http://dx.doi.org/10.3390/molecules24081528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514607/
https://www.ncbi.nlm.nih.gov/pubmed/31003424
http://dx.doi.org/10.3390/molecules24081528

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