Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor

Small-molecule HIV-1 entry inhibitors are an extremely attractive therapeutic modality. We have previously demonstrated that the entry inhibitor class can be optimized by using computational means to identify and extend the chemotypes available. Here we demonstrate unique and differential effects of...

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Detalles Bibliográficos
Autores principales: Meuser, Megan E., Rashad, Adel A., Ozorowski, Gabriel, Dick, Alexej, Ward, Andrew B., Cocklin, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514670/
https://www.ncbi.nlm.nih.gov/pubmed/31013646
http://dx.doi.org/10.3390/molecules24081581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514670/
https://www.ncbi.nlm.nih.gov/pubmed/31013646
http://dx.doi.org/10.3390/molecules24081581

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