QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer’s Disease Therapy

We report the synthesis and relevant pharmacological properties of the quinoxalinetacrine (QT) hybrid QT78 in a project targeted to identify new non-hepatotoxic tacrine derivatives for Alzheimer’s disease therapy. We have found that QT78 is less toxic than tacrine at high concentrations (from 100 μM...

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Detalles Bibliográficos
Autores principales: Ramos, Eva, Palomino-Antolín, Alejandra, Bartolini, Manuela, Iriepa, Isabel, Moraleda, Ignacio, Diez-Iriepa, Daniel, Samadi, Abdelouahid, Cortina, Carol V., Chioua, Mourad, Egea, Javier, Romero, Alejandro, Marco-Contelles, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514705/
https://www.ncbi.nlm.nih.gov/pubmed/30999586
http://dx.doi.org/10.3390/molecules24081503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514705/
https://www.ncbi.nlm.nih.gov/pubmed/30999586
http://dx.doi.org/10.3390/molecules24081503

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