A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A

Kinases regulate multiple and diverse signaling pathways and misregulation is implicated in a multitude of diseases. Although significant efforts have been put forth to develop kinase-specific inhibitors, specificity remains a challenge. As an alternative to catalytic inhibition, allosteric inhibito...

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Detalles Bibliográficos
Autores principales: Manschwetus, Jascha T., Bendzunas, George N., Limaye, Ameya J., Knape, Matthias J., Herberg, Friedrich W., Kennedy, Eileen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514771/
https://www.ncbi.nlm.nih.gov/pubmed/31009996
http://dx.doi.org/10.3390/molecules24081567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514771/
https://www.ncbi.nlm.nih.gov/pubmed/31009996
http://dx.doi.org/10.3390/molecules24081567

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