Targeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS)

In cells, thymidylate synthases provide the only de novo source of 2′-deoxythymidine-5′-monophosphate (dTMP), required for DNA synthesis. The activity of these enzymes is pivotal for cell survival and proliferation. Two main families of thymidylate synthases have been identified in bacteria, folate-...

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Detalles Bibliográficos
Autores principales: Pozzi, Cecilia, Lopresti, Ludovica, Tassone, Giusy, Mangani, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514825/
https://www.ncbi.nlm.nih.gov/pubmed/31027295
http://dx.doi.org/10.3390/molecules24081638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514825/
https://www.ncbi.nlm.nih.gov/pubmed/31027295
http://dx.doi.org/10.3390/molecules24081638

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