GDNF-mediated rescue of the nigrostriatal system depends on the degree of degeneration

Glial cell-line derived neurotrophic factor (GDNF) is a promising therapeutic molecule to treat Parkinson’s disease. Despite an excellent profile in experimental settings, clinical trials testing GDNF have failed. One of the theories to explain these negative outcomes is that the clinical trials wer...

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Detalles Bibliográficos
Autores principales: Quintino, Luis, Avallone, Martino, Brännstrom, Emil, Kavanagh, Patrick, Lockowandt, Marcus, Garcia Jareño, Patricia, Breger, Ludivine S, Lundberg, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514883/
https://www.ncbi.nlm.nih.gov/pubmed/30531868
http://dx.doi.org/10.1038/s41434-018-0049-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514883/
https://www.ncbi.nlm.nih.gov/pubmed/30531868
http://dx.doi.org/10.1038/s41434-018-0049-0

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