Cargando…

GDNF-mediated rescue of the nigrostriatal system depends on the degree of degeneration

Glial cell-line derived neurotrophic factor (GDNF) is a promising therapeutic molecule to treat Parkinson’s disease. Despite an excellent profile in experimental settings, clinical trials testing GDNF have failed. One of the theories to explain these negative outcomes is that the clinical trials wer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Quintino, Luis, Avallone, Martino, Brännstrom, Emil, Kavanagh, Patrick, Lockowandt, Marcus, Garcia Jareño, Patricia, Breger, Ludivine S, Lundberg, Cecilia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514883/ https://www.ncbi.nlm.nih.gov/pubmed/30531868 http://dx.doi.org/10.1038/s41434-018-0049-0

Ejemplares similares

Destabilizing Domains Enable Long-Term and Inert Regulation of GDNF Expression in the Brain
por: Quintino, Luis, et al.
Publicado: (2018)

GDNF-based therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson’s disease
por: d’Anglemont de Tassigny, Xavier, et al.
Publicado: (2015)

Striatonigral neurons divide into two distinct morphological-physiological phenotypes after chronic L-DOPA treatment in parkinsonian rats
por: Fieblinger, T., et al.
Publicado: (2018)

GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function
por: Kumar, Anmol, et al.
Publicado: (2015)

Correction: GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function
por: Kumar, Anmol, et al.
Publicado: (2016)

Aged Tgfβ2/Gdnf double-heterozygous mice show no morphological and functional alterations in the nigrostriatal system
por: Heermann, Stephan, et al.
Publicado: (2010)

A regulatable AAV vector mediating GDNF biological effects at clinically-approved sub-antimicrobial doxycycline doses
por: Chtarto, Abdelwahed, et al.
Publicado: (2016)

The amygdalo-nigrostriatal network is critical for an optimal temporal performance
por: Es-seddiqi, Mouna, et al.
Publicado: (2016)

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration
por: Mor, Danielle E., et al.
Publicado: (2017)

GDNF to the rescue: GDNF delivery effects on motor neurons and nerves, and muscle re-innervation after peripheral nerve injuries
por: Cintrón-Colón, Alberto F., et al.
Publicado: (2021)

Clinical Features Indicating Nigrostriatal Dopaminergic Degeneration in Drug-Induced Parkinsonism
por: Lee, Seung Ha, et al.
Publicado: (2017)

Diabetes Causes Dysfunctional Dopamine Neurotransmission Favoring Nigrostriatal Degeneration in Mice
por: Pérez‐Taboada, Iara, et al.
Publicado: (2020)

Absence of Ret Signaling in Mice Causes Progressive and Late Degeneration of the Nigrostriatal System
por: Kramer, Edgar R, et al.
Publicado: (2007)

Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons
por: Bayliss, Jacqueline A., et al.
Publicado: (2016)

Premorbid performances determine the deleterious effects of nigrostriatal degeneration and pramipexole on behavioural flexibility
por: Decourt, Mélina, et al.
Publicado: (2023)

Neuroprotective effects of GSK-343 in an in vivo model of MPTP-induced nigrostriatal degeneration
por: Mannino, Deborah, et al.
Publicado: (2023)

Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression
por: Wang, Yong, et al.
Publicado: (2020)

Brain glucose metabolism and nigrostriatal degeneration in isolated rapid eye movement sleep behaviour disorder
por: Diaz-Galvan, Patricia, et al.
Publicado: (2023)

Rescue effects of intravitreal aflibercept in the treatment of neovascular age-related macular degeneration
por: Hsia, Ning-Yi, et al.
Publicado: (2015)

Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit
por: Pham, Anh H., et al.
Publicado: (2012)

Metabolic Covariant Network in Relation to Nigrostriatal Degeneration in Carbon Monoxide Intoxication-Related Parkinsonism
por: Chang, Chiung-Chih, et al.
Publicado: (2016)

Urinary Dysfunction Is Associated with Nigrostriatal Dopaminergic Degeneration in Early and Untreated Patients with Parkinson's Disease
por: Wang, Jing, et al.
Publicado: (2020)

Astrocytes and retrograde degeneration of nigrostriatal dopaminergic neurons in Parkinson’s disease: removing axonal debris
por: Morales, Ingrid, et al.
Publicado: (2021)

A Mouse Model of Nigrostriatal Dopaminergic Axonal Degeneration As a Tool for Testing Neuroprotectors
por: Kolacheva, A. A., et al.
Publicado: (2021)

Naringin as a beneficial natural product against degeneration of the nigrostriatal dopaminergic projection in the adult brain
por: Kim, Sang Ryong
Publicado: (2017)

Degeneration of nigrostriatal pathway in patients with middle cerebral infarct: A diffusion tensor imaging study
por: Seo, Jeong Pyo, et al.
Publicado: (2022)

Allopregnanolone and neurogenesis in the nigrostriatal tract
por: Wang, Jun Ming
Publicado: (2014)

Dexamethasone to the rescue
por: Moon, Chang
Publicado: (2020)

Assessment of Repetitive and Compulsive Behaviors Induced by Pramipexole in Rats: Effect of Alpha-Synuclein-Induced Nigrostriatal Degeneration
por: Decourt, Mélina, et al.
Publicado: (2022)

Microglial depletion does not impact alpha-synuclein aggregation or nigrostriatal degeneration in the rat preformed fibril model
por: Stoll, Anna C., et al.
Publicado: (2023)

Associated degeneration of ventral tegmental area dopaminergic neurons in the rat nigrostriatal lactacystin model of parkinsonism and their neuroprotection by valproate
por: Harrison, Ian F., et al.
Publicado: (2016)

Progressive Axonal Degeneration of Nigrostriatal Dopaminergic Neurons in Calcium-Independent Phospholipase A(2)β Knockout Mice
por: Beck, Goichi, et al.
Publicado: (2016)

Human Neural Progenitors Expressing GDNF Enhance Retinal Protection in a Rodent Model of Retinal Degeneration
por: Shahin, Saba, et al.
Publicado: (2023)

The Future of GDNF in Parkinson's Disease
por: Manfredsson, Fredric P., et al.
Publicado: (2020)

SINEUP Non-coding RNA Targeting GDNF Rescues Motor Deficits and Neurodegeneration in a Mouse Model of Parkinson’s Disease
por: Espinoza, Stefano, et al.
Publicado: (2020)

Photoreceptor preservation induced by intravitreal controlled delivery of GDNF and GDNF/melatonin in rhodopsin knockout mice
por: García-Caballero, Cristina, et al.
Publicado: (2018)

Naringin: A Protector of the Nigrostriatal Dopaminergic Projection
por: Jung, Un Ju, et al.
Publicado: (2014)

The GDNF Family: A Role in Cancer?
por: Fielder, Graeme C., et al.
Publicado: (2017)

TGF-β1 Increases GDNF Production by Upregulating the Expression of GDNF and Furin in Human Granulosa-Lutein Cells
por: Yin, Jingwen, et al.
Publicado: (2020)

Postsynaptic nigrostriatal dopamine receptors and their role in movement regulation
por: Korchounov, Alexei, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_nu2400tgp8j402rfdvp21e8tma