Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice

We report the restoration of euglycaemia in chemically induced diabetic C57BL/6 mice and spontaneously diabetic Non Obese Diabetic (NOD) mice by intravenous systemic administration of a single-stranded adeno-associated virus (ssAAV2/8) codon optimised (co) vector encoding furin cleavable human proin...

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Detalles Bibliográficos
Autores principales: Recino, Asha, Gan, Shu Uin, Sia, Kian Chuan, Sawyer, Yvonne, Trendell, Jenny, Kay, Richard, Gribble, Fiona M., Reimann, Frank, Foale, Rob, Notaridou, Maria, Holmes, Nick, Lever, Andrew, Lee, Kok Onn, Nathwani, Amit, Cooke, Anne, Calne, Roy, Wallberg, Maja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514884/
https://www.ncbi.nlm.nih.gov/pubmed/30514969
http://dx.doi.org/10.1038/s41434-018-0052-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514884/
https://www.ncbi.nlm.nih.gov/pubmed/30514969
http://dx.doi.org/10.1038/s41434-018-0052-5

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