Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer’s disease

In addition to the devastating symptoms of dementia, Alzheimer’s disease (AD) is characterized by accumulation of the processing products of the amyloid-β (Aβ) peptide precursor protein (APP). APP’s non-pathogenic functions include regulating intracellular iron (Fe) homeostasis. MicroRNAs are small...

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Detalles Bibliográficos
Autores principales: Long, Justin M., Maloney, Bryan, Rogers, Jack T., Lahiri, Debomoy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Immediate Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514885/
https://www.ncbi.nlm.nih.gov/pubmed/30470799
http://dx.doi.org/10.1038/s41380-018-0266-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514885/
https://www.ncbi.nlm.nih.gov/pubmed/30470799
http://dx.doi.org/10.1038/s41380-018-0266-3

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