FK506 Induces Ligand-Independent Activation of the Bone Morphogenetic Protein Pathway and Osteogenesis

Osteoinductive bone morphogenetic proteins (BMPs), including BMP-2, have a unique capability of mediating bone formation both in orthotopic and ectopic locations. Immunosuppresive macrolides have been shown to potentiate BMP-2 activity through FKBP12, but these have yet to translate to effective ost...

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Detalles Bibliográficos
Autores principales: Sangadala, Sreedhara, Devereaux, Emily J., Presciutti, Steven M., Boden, Scott D., Willet, Nick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515024/
https://www.ncbi.nlm.nih.gov/pubmed/30999619
http://dx.doi.org/10.3390/ijms20081900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515024/
https://www.ncbi.nlm.nih.gov/pubmed/30999619
http://dx.doi.org/10.3390/ijms20081900

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