Cargando…

FK506 Induces Ligand-Independent Activation of the Bone Morphogenetic Protein Pathway and Osteogenesis

Osteoinductive bone morphogenetic proteins (BMPs), including BMP-2, have a unique capability of mediating bone formation both in orthotopic and ectopic locations. Immunosuppresive macrolides have been shown to potentiate BMP-2 activity through FKBP12, but these have yet to translate to effective ost...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sangadala, Sreedhara, Devereaux, Emily J., Presciutti, Steven M., Boden, Scott D., Willet, Nick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515024/ https://www.ncbi.nlm.nih.gov/pubmed/30999619 http://dx.doi.org/10.3390/ijms20081900

Ejemplares similares

Correction: Sangadala, S. et al. FK506 Induces Ligand-Independent Activation of the Bone Morphogenetic Protein Pathway and Osteogenesis. Int. J. Mol. Sci. 2019, 20, 1900
por: Sangadala, Sreedhara, et al.
Publicado: (2020)

Sclerostin small-molecule inhibitors promote osteogenesis by activating canonical Wnt and BMP pathways
por: Sangadala, Sreedhara, et al.
Publicado: (2023)

Interactions of FK506 and Rapamycin With FK506 Binding Protein 12 in Opportunistic Human Fungal Pathogens
por: Vellanki, Sandeep, et al.
Publicado: (2020)

Maculopathy Associated with Tacrolimus (FK 506)
por: Koh, Taehyuk, et al.
Publicado: (2011)

The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin
Publicado: (1992)

The Effect of FK 506 on the Reepithelialization of Superficial Skin Wound
por: Shin, Jeong Min, et al.
Publicado: (2017)

Natural product ligands of FKBP12: Immunosuppressive antifungal agents FK506, rapamycin, and beyond
por: Rivera, Angela, et al.
Publicado: (2023)

FK506-Binding Protein 2 Participates in Proinsulin Folding
por: Hoefner, Carolin, et al.
Publicado: (2023)

FK506 regulates Ca(2+) release evoked by inositol 1,4,5‐trisphosphate independently of FK‐binding protein in endothelial cells
por: Buckley, Charlotte, et al.
Publicado: (2020)

Effects of FK506 on Ca(2+) Release Channels (Review)
por: Ozawa, Terutaka
Publicado: (2008)

Molecular Evolution of the Vertebrate FK506 Binding Protein 25
por: Liu, Fei, et al.
Publicado: (2014)

FK506 attenuates thymic output in patients with myasthenia gravis
por: Mitsui, Takao, et al.
Publicado: (2013)

FK506 immunosuppression for submandibular salivary gland allotransplantation in rabbit
por: Almansoori, Akram Abdo, et al.
Publicado: (2020)

Role of FK506-sensitive signals in asthmatic lung inflammation
por: Tomiaki, Chihiro, et al.
Publicado: (2022)

49. Recruited Macrophages are Required for Neuroenhancing Effects of Fk506
por: Broberg, Curtis, et al.
Publicado: (2023)

Advancing Nerve Regeneration: Translational Perspectives of Tacrolimus (FK506)
por: Daeschler, Simeon C., et al.
Publicado: (2023)

An improved reversibly dimerizing mutant of the FK506-binding protein FKBP
por: Barrero, Juan J., et al.
Publicado: (2016)

FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury
por: Lee, Bohm, et al.
Publicado: (2022)

FK506 increases susceptibility to musculoskeletal infection in a rodent model
por: Shiels, Stefanie M., et al.
Publicado: (2022)

Use of FK506 and bone marrow mesenchymal stem cells for rat hind limb allografts☆
por: Song, Youxin, et al.
Publicado: (2012)

Identification of Tropoelastin as a Ligand for the 65-kD FK506-binding Protein, FKBP65, in the Secretory Pathway
por: Davis, Elaine C., et al.
Publicado: (1998)

Abstract 134: FK506 Delivering Conduit For Peripheral Nerve Regeneration
por: Labroo, Pratima, et al.
Publicado: (2017)

Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35
por: Atack, Thomas C., et al.
Publicado: (2020)

FK506 Attenuated Pilocarpine-Induced Epilepsy by Reducing Inflammation in Rats
por: Wang, Aihua, et al.
Publicado: (2019)

Optimization of the precursor supply for an enhanced FK506 production in Streptomyces tsukubaensis
por: Schulz, Susann, et al.
Publicado: (2022)

Development of Non-Immunosuppressive FK506 Derivatives as Antifungal and Neurotrophic Agents
por: Jung, Jin A, et al.
Publicado: (2020)

EFFECTS OF FK506 ON THE HEALING OF DIAPHYSEAL, CRITICAL SIZE DEFECTS IN THE RAT FEMUR
por: De la Vega, R.E., et al.
Publicado: (2020)

Impairment of early fracture healing by skeletal muscle trauma is restored by FK506
por: Hurtgen, Brady J., et al.
Publicado: (2017)

Association of long-term tacrolimus (FK506) therapy with abnormal megakaryocytosis, bone marrow fibrosis, and dyserythropoiesis
por: Yang, Zhongbo, et al.
Publicado: (2015)

Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus
por: Hoy, Michael J., et al.
Publicado: (2022)

FK506-binding protein 51 is a possible novel tumoral marker
por: Romano, S, et al.
Publicado: (2010)

Genome-Wide Screening for Genes Associated with FK506 Sensitivity in Fission Yeast
por: Ma, Yan, et al.
Publicado: (2011)

Neuroprotective effects of Tacrolimus (FK-506) and Cyclosporin (CsA) in oxidative injury
por: Yousuf, Seema, et al.
Publicado: (2011)

Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?
por: Sieber, Matthias, et al.
Publicado: (2009)

The Emerging Role of Large Immunophilin FK506 Binding Protein 51 in Cancer
por: Romano, S, et al.
Publicado: (2011)

FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis
por: Goranovič, Dušan, et al.
Publicado: (2012)

FK506 reduces calpain-regulated calcineurin activity in both the cytoplasm and the nucleus
por: Lee, Sun Hee, et al.
Publicado: (2014)

Analysing the visible conformational substates of the FK506-binding protein FKBP12
por: Mustafi, Sourajit M., et al.
Publicado: (2013)

A case of reversible toxic optic neuropathy from tacrolimus (FK506)
por: Gokoffski, Kimberly K., et al.
Publicado: (2020)

Treatment With Calcineurin Inhibitor FK506 Attenuates Noise-Induced Hearing Loss
por: He, Zu-Hong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9i04vtu8ptgvl90g37cf1g52pt