Targeting Platelet GPVI Plus rt-PA Administration but Not α2β1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice

Platelet collagen interactions at sites of vascular injuries predominantly involve glycoprotein VI (GPVI) and the integrin α2β1. Both proteins are primarily expressed on platelets and megakaryocytes whereas GPVI expression is also shown on endothelial and integrin α2β1 expression on epithelial cells...

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Detalles Bibliográficos
Autores principales: Schuhmann, Michael K., Kraft, Peter, Bieber, Michael, Kollikowski, Alexander M., Schulze, Harald, Nieswandt, Bernhard, Pham, Mirko, Stegner, David, Stoll, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515069/
https://www.ncbi.nlm.nih.gov/pubmed/31022936
http://dx.doi.org/10.3390/ijms20082019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515069/
https://www.ncbi.nlm.nih.gov/pubmed/31022936
http://dx.doi.org/10.3390/ijms20082019

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