Development of Highly Selective 1,2,3-Triazole-containing Peptidic Polo-like Kinase 1 Polo-box Domain-binding Inhibitors

Members of the polo-like kinase (Plk) family of serine/threonine protein kinases play crucial roles in cell cycle regulation and proliferation. Of the five Plks (Plk1–5), Plk1 is recognized as an anticancer drug target. Plk1 contains multiple structural components that are important for its proper b...

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Detalles Bibliográficos
Autores principales: Zhao, Xue Zhi, Tsuji, Kohei, Hymel, David, Burke, Terrence R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515314/
https://www.ncbi.nlm.nih.gov/pubmed/31014020
http://dx.doi.org/10.3390/molecules24081488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515314/
https://www.ncbi.nlm.nih.gov/pubmed/31014020
http://dx.doi.org/10.3390/molecules24081488

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