Ligand Selectivity in the Recognition of Protoberberine Alkaloids by Hybrid-2 Human Telomeric G-Quadruplex: Binding Free Energy Calculation, Fluorescence Binding, and NMR Experiments

The human telomeric G-quadruplex (G4) is an attractive target for developing anticancer drugs. Natural products protoberberine alkaloids are known to bind human telomeric G4 and inhibit telomerase. Among several structurally similar protoberberine alkaloids, epiberberine (EPI) shows the greatest spe...

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Detalles Bibliográficos
Autores principales: Deng, Nanjie, Xia, Junchao, Wickstrom, Lauren, Lin, Clement, Wang, Kaibo, He, Peng, Yin, Yunting, Yang, Danzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515380/
https://www.ncbi.nlm.nih.gov/pubmed/31010072
http://dx.doi.org/10.3390/molecules24081574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515380/
https://www.ncbi.nlm.nih.gov/pubmed/31010072
http://dx.doi.org/10.3390/molecules24081574

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