Structure–Activity Relationships of the Tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH(2) at the Mouse Melanocortin Receptors: Modification at the (pI)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands

The five melanocortin receptors (MC1R–MC5R) are involved in numerous biological pathways, including steroidogenesis, pigmentation, and food intake. In particular, MC3R and MC4R knockout mice suggest that the MC3R and MC4R regulate energy homeostasis in a non-redundant manner. While MC4R-selective ag...

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Detalles Bibliográficos
Autores principales: Schlasner, Katherine N., Ericson, Mark D., Doering, Skye R., Freeman, Katie T., Weinrich, Mary, Haskell-Luevano, Carrie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515519/
https://www.ncbi.nlm.nih.gov/pubmed/31013889
http://dx.doi.org/10.3390/molecules24081463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515519/
https://www.ncbi.nlm.nih.gov/pubmed/31013889
http://dx.doi.org/10.3390/molecules24081463

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