Exercise activates lysosomal function in the brain through AMPK‐SIRT1‐TFEB pathway

AIM: To study the effects of exercise on lysosomal functions. METHODS: Mouse exercise model was established and wheel running was scheduled as 18 rpm (14:00‐17:00), 5 d/wk, for 8 weeks. Mice were injected EX527 to inhibit SIRT1 activity. The protein level was assayed with Western blot and immunofluo...

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Detalles Bibliográficos
Autores principales: Huang, Jun, Wang, Xue, Zhu, Yi, Li, Zhe, Zhu, Yu‐Ting, Wu, Jun‐Chao, Qin, Zheng‐Hong, Xiang, Min, Lin, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515701/
https://www.ncbi.nlm.nih.gov/pubmed/30864262
http://dx.doi.org/10.1111/cns.13114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515701/
https://www.ncbi.nlm.nih.gov/pubmed/30864262
http://dx.doi.org/10.1111/cns.13114

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