Apn2 Resolves Blocked 3’ Ends and Suppresses Top1-Induced Mutagenesis at Genomic rNMP Sites.

Ribonucleotides (rNMPs) mis-incorporated during DNA replication are removed by RNase H2 dependent excision repair or by Topoisomerase I – catalyzed cleavage. Top1 cleavage of rNMPs produces 3’ ends harboring terminal adducts, such as 2’, 3’ cyclic phosphate or Top1 cleavage complex (Top1cc), and lea...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Fuyang, Wang, Quan, Seol, Ja-Hwan, Che, Jun, Lu, Xiaoyu, Shim, Eun Yong, Lee, Sang Eun, Niu, Hengyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515903/
https://www.ncbi.nlm.nih.gov/pubmed/30778235
http://dx.doi.org/10.1038/s41594-019-0186-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515903/
https://www.ncbi.nlm.nih.gov/pubmed/30778235
http://dx.doi.org/10.1038/s41594-019-0186-1

Ejemplares similares