Cargando…
Apn2 Resolves Blocked 3’ Ends and Suppresses Top1-Induced Mutagenesis at Genomic rNMP Sites.
Ribonucleotides (rNMPs) mis-incorporated during DNA replication are removed by RNase H2 dependent excision repair or by Topoisomerase I – catalyzed cleavage. Top1 cleavage of rNMPs produces 3’ ends harboring terminal adducts, such as 2’, 3’ cyclic phosphate or Top1 cleavage complex (Top1cc), and lea...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515903/ https://www.ncbi.nlm.nih.gov/pubmed/30778235 http://dx.doi.org/10.1038/s41594-019-0186-1 |