Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3

TGF-β1 is a critical mediator of tissue fibrosis in health and disease whose effects are augmented by chitinase 1 (CHIT1). However, the mechanisms that CHIT1 uses to regulate TGF-β1–mediated fibrotic responses have not been defined. Here, we demonstrate that CHIT1 enhances TGF-β1–stimulated fibrotic...

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Detalles Bibliográficos
Autores principales: Lee, Chang-Min, He, Chuan-Hua, Park, Jin Wook, Lee, Jae Hyun, Kamle, Suchita, Ma, Bing, Akosman, Bedia, Cotez, Roberto, Chen, Emily, Zhou, Yang, Herzog, Erica L, Ryu, Changwan, Peng, Xueyan, Rosas, Ivan O, Poli, Sergio, Bostwick, Carol Feghali, Choi, Augustine M, Elias, Jack A, Lee, Chun Geun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516052/
https://www.ncbi.nlm.nih.gov/pubmed/31085559
http://dx.doi.org/10.26508/lsa.201900350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516052/
https://www.ncbi.nlm.nih.gov/pubmed/31085559
http://dx.doi.org/10.26508/lsa.201900350

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